Antifibrin action of phenformin
نویسندگان
چکیده
منابع مشابه
Phenformin (Dibotin) in polyarthritis.
Since 1956 biguanides have received attention as oral hypoglycaemic agents (Krall and Bradley, 1959). Ungar, Madison, and Carter (1960), using phenformin (Dibotin, phenethyl biguanide), showed their effect on peripheral utilization of glucose, Butterfield, Fry, and Holling (1958) having previously demonstrated increased uptake of insulin in hepatic and peripheral tissues. Since then the drug ha...
متن کاملPhenformin and lactic acidosis.
Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for la...
متن کاملPhenformin and pulmonary hypertension.
Two cases with clinical signs ofpulmonary hypertension and right heart failure developing during phenformin treatment are reported. The patients were clinically improved on withdrawal of phenformin. Two possible explanations for the pulmonary hypertension were considered: cellular anaerobiosis or alphareceptor stimulation of the pulmonary vessels. The 4 patients sofar reported direct attention ...
متن کاملAn antifibrin monoclonal antibody useful in immunoscintigraphic detection of thrombi.
Balb/c mice were immunized with human plasmin-generated fibrinogen degradation product Y. Spleen cells were fused with P3X63-Ag8.653 myeloma cells. A clone (Y22) was found that produces monoclonal antibodies (MoAbs) with a strong reactivity with human fibrin and only a weak reactivity with fibrinogen in an enzyme immunoassay (EIA). Y22 also reacts with fibrin of rabbits, rats, sheep, and dogs. ...
متن کاملThe genetic control of phenformin 4-hydroxylation.
Previously published results of phenformin 4-hydroxylation in 195 unrelated white British volunteers and 87 family members of 27 randomly selected probands have been subjected to genetic analysis. The results clearly show that about 9% of this population has a genetically determined defect in carrying out this oxidation reaction. The character for the defect is inherited in a Mendelian autosoma...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1975
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00429832